В основе биологической активности красного перца лежит капсаицин (capsaicin). Литература


В основе биологической активности красного перца лежит капсаицин

  1. Akagi, A., Sano, N., Uehara, H., Minami, T., Otsuka, H. and Izumi, K. (1998), Non-carcinogencity of capsaicinoids in B6C3F1 mice. Food Chem. Toxicol. 36:1065–1071.
  2. Anand, P. and Bley, K. (2011), Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch. Br. J. Anaesth. 107:490–502.
  3. Anandakumar, P., Kamaraj, S., Jagan, S., Ramakrishnan, G., Asokkumar, S., Naveenkumar, C., Raghunandhakumar, S. and Devaki, T. (2012). Capsaicin inhibits benzo(a)pyrene-induced lung carcinogenesis in an in vivo mouse model. Inflamm. Res. 61:1169–1175.
  4. Arnold, W. P. and van de Kerkhof, P. C. (1993). Topical capsaicin in pruritic psoriasis. J. Am. Acad. Dermatol. 29:438–442.
  5. Babu, P. S. and Srinivasan, K. (1997). Influence of dietary capsaicin and onion on the metabolic abnormalities associated with diabetes mellitus. Mol. Cell. Biochem. 175:49–57.
  6. Bartholomew, L. G. and Carlson, H. C. (1994). An unusual case of gastroenteritis. Mayo Clin. Proc. 69:675–676.
  7. Bernstein, J. E. (1989). Treatment of chronic post-herpetic neuralgia with topical capsaicin. Am. J. Dermatol. 21:265–270.
  8. Bhat, B. G., Srinivasan, M. R. and Chandrasekhara, N. (1984). Influence of curcumin and capsaicin on the composition and secretion of bile in rats. J. Food Sci. Technol. 21:225–227.
  9. Bode, A. M. and Dong, Z. (2011). The two faces of capsaicin. Cancer Res. 71:2809–2814.
  10. Brown, M. and Vale, W. (2011). Effects of neurotensin and substance P on plasma insulin, glucagon and glucose levels. Endocrinology 98:819–822.
  11. Buiatti, E., Palli, D., Decarli, A., Amadori, D., Avellini, C., Bianchi, S., Biserni R, Cipriani F, Cocco P, Giacosa A. (1989). A case-control study of gastric cancer and diet in Italy. Int. J. Cancer 44:611–616.
  12. Carpenter, S. and Lynn, B. (1981). Abolition of axon reflex flare in human skin by capsaicin. J. Physiol. (Lond.) 310:69P–70P.
  13. Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D. and Julius, D. (1997). The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816–824.
  14. Cazana, F. J. D., Puyol, M. R., Caballero, J. P., Jimenez, A. J. and Duarte, A. M. (1990). Effect of dietary hyperlipidemia-hypercholesterolemia on rat erythrocytes. Int. J. Vitam. Nutr. Res. 60:393–397.
  15. Chanda, S., Sharper, V. A., Hoberman, A. M. and Bley, K. (2006). Developmental toxicity study of pure trans-capsaicin in rats and rabbits. Int. J. Toxicol. 25:205–217.
  16. Deal, C. L. (1991). Effect of topical capsaicin: A double blind trial. Clin. Therap. 13:383–395.
  17. Derry, S., Lloyd, R., Moore, R. A. and McQuay, H. J. (2009). Topical capsaicin for chronic neuropathic pain in adults (Review). Cochrane Database of Systematic Reviews Oct. 7(4):. Art. No. CD007393
  18. Diepvens, K., Westerterp, K. R. and Westerterp-Plantenga, M. S. (2007). Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292:R77–R85.
  19. Fitzgerald, M. (1983). Capsaicin and sensory neurons– A Review. Pain 15:109–139.
  20. Fraenkel, L., Bogardus, S. T., Concato, J. and Wittink, D. R. (2004). Treatment options in knee osteoarthritis: The patient’s perspective. Arch. Intern. Med. 164:1299–1304.
  21. Fujiwake, H., Suzuki, T., Oka, S. and Iwai, K. (1980). Enzymatic formation of capsaicinoid from vanillylamine and iso-type fatty acids by cell-free extracts of Capsicum annuum var. annuum. Agric. Biol. Chem. 44:2907–2912.[Taylor & Francis Online],
  22. Fuller, R. W., Dixon, C. M. S. and Barnes, P. J. (1985). Broncho-constrictor response to inhaled capsaicin in humans. J. Appl. Physiol. 58:1080–1084.
  23. Geppetti, P., Nassini, R., Materazzi, S. and Benemei, S. (2008). The concept of neurogenic inflammation. BJU Int. 101:2–6.
  24. Glinski, W., Glinska-Ferenz, M. and Pierozynska-Dubowska, M. (1991). Neurogenic inflammation induced by capsaicin in patients with psoriasis. Acta Derm. Venereol. 71:51–54.
  25. Goldfrank, L. R. (ed). (2002). Goldfrank’s Toxicologic Emergencies. 7th ed., McGraw-Hill, New York, p. 1167.
  26. Govindarajan, V. S. (1986). Capsicum — production, technology, chemistry and quality: chemistry of colour, aroma and pungency stimuli. Crit. Rev. Food Sci. Nutr. 24:245–355.[Taylor & Francis Online],
  27. Gupta, R. S., Dixit, V. P., Dobhal, M. P. (2002). Hypocholesterolemic effect of the oleoresin of Capsicum annum L. in gerbils (Meriones hurrianae Jerdon). Phytother. Res. 16:273–275.
  28. Hussain, M. S. and Chandrasekhara, N. (1992.) Effect of curcumin on cholesterol gallstone induction in mice. Indian J. Med. Res. 96:288–291.
  29. Hussain, M. S. and Chandrasekhara, N. (1993). Influence of curcumin and capsaicin on cholesterol gallstone induction in hamsters and mice. Nutr. Res. 13:349–357.
  30. Hussain, M. S. and Chandrasekhara, N. (1994a). Biliary proteins from hepatic bile of rats fed curcumin or capsaicin inhibit cholesterol crystal nucleation in supersaturated model bile. Indian J. Biochem. Biophys. 31:407–412.
  31. Hussain, M. S. and Chandrasekhara, N. (1994b). Effect of curcumin and capsaicin on the regression of pre-established cholesterol gallstones in mice. Nutr. Res. 14:1561–1574.
  32. Ito, K., Nakazato, T., Yamato, K., Miyakawa, Y., Yamada, T., Hozumi, N., et al. (2004). Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species. Cancer Res. 64:1071–1078.
  33. Jancso, G., Kiraly, E. and Jancso-Gabor, A. (1977). Pharmacologically induced selective degeneration of chemosensitive primary neorones. Nature 270:741–743.
  34. Joe, B. and Lokesh, B. R. (1997). Prophylactic and therapeutic effects of n-3 PUFA, capsaicin & curcumin on adjuvant induced arthritis in rats. J. Nutr. Biochem. 8:397–407.
  35. Joe, B. and Lokesh, B. R. (1997a). Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages. Lipids 32:1173–1180.
  36. Kang, J. Y., Yeoh, K. G., Chia, H. P., Lee, H. P., Chia, Y. W., Guan, R. and Yap, I. (1995). Chili protective factor against peptic ulcer? Diges. Dis. Sci. 40:576–579.
  37. Kawada, T., Suzuki, T., Takahashi, M. and Iwai, K. (1984). Gastrointestinal absorption and metabolism of capsaicin and dihydrocapsaicin in rats. Toxicol. Appl. Pharmacol. 72:449– 456.
  38. Kawada, T., Hagihara, K. and Iwai, K. (1986). Effects of capsaicin on lipid metabolism in rats fed a high fat diet. J. Nutr. 116:1272–1278.
  39. Kempaiah, R. K. and Srinivasan, K. (2002). Integrity of erythrocytes of hypercholesterolemic rats during spices treatment. Mol. Cell. Biochem. 236:155–161.
  40. Kempaiah, R. K. and Srinivasan, K. (2004a). Influence of dietary curcumin, capsaicin and garlic on the antioxidant status of red blood cells and the liver in high-fat-fed rats. Ann. Nutr. Metab. 48:314–320.
  41. Kempaiah, R. K. and Srinivasan, K. (2004b). Antioxidant status of red blood cells and liver in hypercholesterolemic rats fed hypolipidemic spices. Int. J. Vitam. Nutr. Res. 74:199–208.
  42. Kempaiah, R. K. and Srinivasan, K. (2005). Influence of dietary spices on the fluidity of erythrocytes in hypercholesterolemic rats. Br. J. Nutr. 93:81–91.
  43. Kempaiah, R. K. and Srinivasan, K. (2006). Beneficial influence of dietary curcumin, capsaicin and garlic on erythrocyte integrity in high-fat fed rats. J. Nutr. Biochem. 17:471–478.
  44. Ki, P., Negulesco, J. A. and Murnane, M. (1982). Decreased total serum myocardial and aortic cholesterol levels following capsaicin treatment. IRCS Med. Sci. 10:446–447.
  45. Kim, C. S., Kawada, T., Kim, B. S., Han, I. S., Choe, S. Y., Kurata, T. and Yu, R. (2003). Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages. Cell Signal. 15:299–306.
  46. Kissin, I. (2008) Vanilloid-induced conduction analgesia: Selective, dose-dependent, long-lasting, with a low level of potential neurotoxicity. Anesthesia Analgesia 107:271–281.
  47. Knotkova, H., Pappagallo, M. and Szallasi, A. (2008). Capsaicin (TRPV1 Agonist) therapy for pain relief: farewell or revival? Clin. Pain 24:142–154.
  48. Kogure, K., Goto, S., Nishimura, M., Yasumoto, M., Abe, K., Ohiwa, C., et al. (2002). Mechanism of potent antiperoxidative effect of capsaicin. Biochim. Biophys. Acta 1573:84–92.
  49. Lee, S. D. (1963). Studies on the influence of diets & lipotropic substances upon the various organs and metabolic changes in rabbits on long term feeding with red pepper. III Metabolic and hematologic changes. Korean J. Intern. Med. 6:708–730.
  50. Lee, C. Y., Kim, M., Yoon, S. W. and Lee, C. H. (2003). Short-term control of capsaicin on blood and oxidative stress of rats in vivo. Phytother. Res. 17:454–458.
  51. Lee, S. H., Krisanapun, C. and Baek, S. J. (2010). NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3beta, C/EBPbeta and ATF3. Carcinogenesis 31:719–728.
  52. Lejeune, M. P. G., Eva, M., Kovacs, M. R., Westerterp-Plantenga, M. S. (2003). Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects. Br. J. Nutr. 90:651–659.
  53. Lewis, R. J. Sr. (ed) (2004). Sax’s Dangerous Properties of Industrial Materials. 11th ed., Wiley-Interscience, Wiley & Sons, Inc., Hoboken, NJ, p. 690.
  54. Liang, Y. T., Tian, X. Y., Chen, J. N., Peng, C., Ma, K. Y., Zuo, Y., Jiao, R., Lu, Y., Huang, Y. and Chen, Z. Y. (2013). Capsaicinoids lower plasma cholesterol and improve endothelial function in hamsters. Eur. J. Nutr. 52:379–388.
  55. Liu, N. C., Hsieh, P. F., Hsieh, M. K., Zeng, Z. M., Cheng, H. L., Liao, J. W. and Chueh, P. J. (2012). Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in vivo. J. Agric. Food Chem. 60:2758–2765.
  56. López-Carrillo, L., López-Cervantes, M., Robles-Díaz, G., Ramírez-Espitia, A., Mohar-Betancourt, A., Meneses-García, A., et al. (2003). Capsaicin consumption, Helicobacter pylori positivity and gastric cancer in Mexico. Int. J. Cancer 106:277–282.
  57. Majid, M., Badmaev, V., Lakshmi, P., Natarajan, S. and Gopinathan, S. (1997). Capsaicin, the Antiarthritic Phytochemical. Nutriscience Publishers Inc., USA.
  58. Manjunatha, H. and Srinivasan, K. (2008). Hypolipidemic and antioxidant potency of heat processed turmeric and red pepper in experimental rats. Afr. J. Food Sci. 2:1–6.
  59. McCarthy, G. M. and McCarthy, D. J. (1991). Effect of topical capsaicin in the therapy of painful osteoarthritis of the hand. J. Rheumatol. 19:604–607.
  60. Monsereenusorn, S. (1983). Subchronic toxicity studies of capsaicin and capsicum in rats. Res. Comm. Chem. Pathol. Pharmacol. 41:95–100.
  61. Mori, A., Lehmann, S., O’Kelly, J., Kumagai, T., Desmond, J. C., Pervan, M., et al. (2006). Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells. Cancer Res. 66:3222–3229.
  62. Muralidhara, and Narasimhamurthy, K. (1988). Non-mutagenicity of capsaicin in albino mice. Food Chem. Toxicol. 26:955–958.
  63. Naidu, K. A. and Thippeswamy, N. B. (2002). Inhibition of human low density lipoprotein oxidation by active principles from spices. Mol. Cell. Biochem. 229:19–23.
  64. Negulesco, J. A., Young, R. M. and Ki, P. (1983). Capsaicin lowers plasma cholesterol and triglycerides of lagomorphs. Artery 12:301–311.
  65. Negulesco, J. A., Noel, S. A., Newman, H. A., Naber, E. C., Bhat, H. B. and Witiak, D. T. (1987). Effects of pure capsaicinoids (capsaicin and dihydrocapsaicin) on plasma lipids and lipoprotein concen-trations of turkey poults. Atherosclerosis 64:85–90.
  66. Okada, Y. and Okajima, H. (2001). Antioxidant effect of capsaicin on lipid peroxidation in homogeneous solution, micelle dispersions & liposomal membranes. Redox. Rep. 6:117–122.[Taylor & Francis Online],
  67. O’Neil, M. J. (ed.) (2001). The Merck Index — An Encyclopedia of Chemicals, Drugs and Biologicals. 13th ed., Whitehouse Station, NJ: Merck and Co., Inc., p. 296.
  68. Pande, S. and Srinivasan, K. (2012). Potentiation of hypolipidemic and weight reducing influence of dietary tender cluster bean (Cyamopsis tetragonoloba) by capsaicin in high-fat fed rats. J. Agric. Food Chem. 60:8155–8162.
  69. Park, J. S., Choi, M. A., Kim, B. S., Han, I. S., Kurata, T. and Yu, R. (2000). Capsaicin protects against ethanol-induced oxidative injury in the gastric mucosa of rats. Life Sci. 67:3087–3093.
  70. Philip, G., Baroody, F. M., Proud, D., Naclerio, R. M. and Togias, A. G. (1994). The human nasal response to capsaicin. J. Allergy Clin. Immunol. 94:1035–1045.
  71. Platel, K. and Srinivasan, K. (1996). Influence of dietary spices or their active principles on digestive enzymes of small intestinal mucosa in rats. Int. J. Food Sci. Nutr. 47:55–59.[Taylor & Francis Online],
  72. Platel, K. and Srinivasan, K. (2000). Influence of dietary spices or their active principles on pancreatic digestive enzymes in albino rats. Nahrung 44:42–46.
  73. Platel, K. and Srinivasan, K. (2001). Studies on the influence of dietary spices on food transit time in experimental rats. Nutr. Res. 21:1309–1314.
  74. Poller, B. S. and Cacroix, J. S. (1993). Capsaicin at the work place. Allergy 48:550.
  75. Prakash, U. N. S. and Srinivasan, K. (2010). Beneficial influence of dietary spices on the ultra structure and fluidity of intestinal brush border in experimental rats. Br. J. Nutr. 104:31–39.
  76. Prakash, U. N. S. and Srinivasan, K. (2012a). Fat digestion and absorption in spice pretreated rats. J. Sci. Food Agri. 92:503–510.
  77. Prakash, U. N. S. and Srinivasan, K. (2012b). Enhanced intestinal uptake of trace minerals in spice pretreated rats. J. Trace Elem. Med. Biol. 27:184–190.
  78. Prasad, N. S., Raghavendra, R., Lokesh, B. R. and Naidu, K. A. (2004). Spice phenolics inhibit human PMNL 5-lipoxygenase. Prostagl. Leukotr. Essent. Fatty Acids 70:521–528.
  79. Razavi, R., Chan, Y., Afifiyan, F. N., Liu, X. J., Wan, X., Yantha, J., et al. (2006). TRPV1 +sensory neurons control β-cell stress and islet inflammation in autoimmune diabetes. Cell 127:1123–1135.
  80. Reddy, A. C. P. and Lokesh, B. R. (1992). Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes. Mol. Cell. Biochem. 111:117–124.
  81. Reddy, A. C. P. and Lokesh, B. R. (1994). Studies on anti-inflammatory activity of spice principles and dietary n-3 polyunsaturated fatty acids on Carrageenan induced inflammation in rats. Ann. Nutr. Metab. 38:349–358.
  82. Reilly, C. A. and Yost, G. S. (2006). Metabolism of capsaicinoids by P450 enzymes: a review of recent findings on reaction mechanisms, bio-activation, and detoxification processes. Drug Metab. Rev. 38:685–706.[Taylor & Francis Online],
  83. Reilly, C. A., Henion, F., Bugni, T. S., Ethirajan, M., Stockmann, C., Pramanik, K. C., Srivastava, S. K., Yost, G. S. (2013). Reactive intermediates produced from the metabolism of the vanilloid ring of capsaicinoids by P450 enzymes. Chem Res Toxicol. 26:55–66.
  84. Richeux, R., Cascante, M., Ennamany, R., Sabureau, D. and Creppy, E. E. (1999). Cytotoxicity and genotoxicity of capsaicin in human neuroblastoma cells SHSY-5Y. Arch. Toxicol. 73:403–409.
  85. Salimath, B. P., Sundaresh, C. S. and Srinivas, L. (1986). Dietary components inhibit lipid peroxidation in erythrocyte membrane. Nutr. Res. 6:1171–1178.
  86. Sambaiah, K., Satyanarayana, M. N. and Rao, M. V. L. (1978). Effect of red pepper and capsaicin on fat absorption and liver fat in rats. Nutr. Rep. Int. 18:521–529.
  87. Sambaiah, K. and Satyanarayana, M. N. (1980). Hypocholesterolemic effect of red pepper and capsaicin. Indian J. Exp. Biol. 18:898–899.
  88. Sambaiah, K., Ratankumar, S., Kamanna, V. S., Satyanarayana, M. N. and Rao, M. V. L. (1982). Influence of turmeric and curcumin on growth, blood constituents and serum enzymes in rats. J. Food Sci. Technol. 19:187–190.
  89. Satyanarayana, M. N. (2006). Capsaicin and gastric ulcers. Crit. Rev. Food Sci. Nutr. 46:275–328.[Taylor & Francis Online],
  90. Shubha, M. C., Reddy, R. L. R. and Srinivasan, K. (2011). Anti-lithogenic influence of dietary capsaicin and curcumin during experimental induction of cholesterol gallstone in mice. Appl. Physiol. Nutr. Metab. 36:201–209.


  1. Srinivasan, K. and Sambaiah, K. (1991). Effect of spices on cholesterol-7α-hydroxylase activity and on serum and hepatic cholesterol levels in the rat. Int. J. Vitam. Nutr. Res. 61:364–369.
  2. Srinivasan, K., Sambaiah, K. and Chandrasekhara, N. (1992). Loss of active principles of common spices during domestic cooking. Food Chem. 43:271–274.
  3. Srinivasan, M. R., Sambaiah, K., Satyanarayana, M. N. and Rao, M. V. L. (1980). Influence of red pepper and capsaicin on growth, blood constituents and nitrogen balance in rats. Nutr. Rep. Int. 21:455–467.
  4. Srinivasan, M. R. and Satyanarayana, M. N. (1987). Influence of capsaicin, curcumin and ferulic acid in rats fed high fat diets. J. Biosci. 12:143–152.
  5. Srinivasan, M. R. and Satyanarayana, M. N. (1988). Influence of capsaicin, eugenol, curcumin and ferulic acid on sucrose induced hypertriglyceridemia in rats. Nutr. Rep, Int. 38:571–581.
  6. Story, G. M. and Crus-Orengo, L. (2007). Feel the burn. Am. Scientist, 95:326–333.
  7. Suresh, D., Manjunatha, H. and Srinivasan, K. (2007). Effect of heat processing of spices on the concentrations of their bioactive principles: turmeric (Curcuma longa), red pepper (Capsicum annuum) and black pepper (Piper nigrum). J. Food Compos. Anal. 20:346–351.
  8. Suresh, D. and Srinivasan, K. (2010). Tissue distribution and elimination of capsaicin, piperine and curcumin following oral intake in rats. Indian J. Med. Res. 131:682–691.
  9. Surh, Y. J. and Lee, S. S. (1995). Capsaicin, a double-edged sword: Toxicity, metabolism, and chemo-preventive potential. Life Sci. 56:1845–1855.
  10. Surh, Y. J., Lee, R. C., Park, K. K., Mayne, S. T., Liem, A. and Miller, J. A. (1995). Chemoprotective effects of capsaicin and diallyl sulfide against mutagenesis or tumorigenesis by vinyl carbamate and N-nitrosodimethylamine. Carcinogenesis 16:2467–2471.
  11. Surh, Y. J., Kundu, J. K., Na, H. K. and Lee, J. S. (2005). Redox-sensitive transcription factors as prime targets for chemoprevention with anti-inflammatory and antioxidative phytochemicals. J. Nutr. 135(Suppl.):2993S–301S.
  12. The Capsaicin Study Group. (1992). Effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy. Diabetic Care 15:159–165.
  13. Thomson Micromedex. (2006). Drug Information for the Health Care Professional. 1, Greenwood Village, CO., p. 763.
  14. Toth, B. and Gannett, P. (1992). Carcinogenicity of lifelong administration of capsaicin of hot pepper in mice. In Vivo 6:59–63.
  15. Tsui, H., Razavi, R., Chan, Y., Yantha, J. and Dosch, H. M. (2007). Sensing autoimmunity in type 1 diabetes. Trends Mol. Med. 13:405–413.
  16. Veda, S. and Srinivasan, K. (2009). Influence of dietary spices—Black pepper, red pepper and ginger on the uptake of β-carotene by rat intestines. J. Funct. Foods 1:394–398.
  17. Veda, S. and Srinivasan, K. (2011). Influence of dietary spices on the in vivo absorption of ingested β-carotene in experimental rats. Br. J. Nutr. 105:1429–1438.
  18. Westerterp-Plantenga, M. S., Smeets, A. and Lejeune, M. P. G. (2004). Sensory and gastro intestinal satiety effects of capsaicin on food intake. J. Obesity 29:682–688.
  19. Yoneshiro, T., Aita, S., Kawai, Y., Iwanaga, T. and Saito, M. (2012). Non-pungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am. J. Clin. Nutr. 95:845–850.


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